AMP Generation - AIPAMPDS

Generate Antimicrobial Peptides

Generate novel antimicrobial peptides using our GPT-based models. Choose a training model, specify the peptide length and quantity, then submit to start generation.

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📊 Scoring System Explanation

Model Scores

AMP Score: Probability of being an antimicrobial peptide (0-1)

Threshold: 0.998
Score > 0.998 → Predicted as AMP (+1 point)

E.coli Score: Probability of antimicrobial activity against E.coli (0-1)

Threshold: 0.9980798959732056
Score > threshold → Active against E.coli (+1 point)
Only evaluated for Broad-spectrum and Gram-negative targets

S.aureus Score: Probability of antimicrobial activity against S.aureus (0-1)

Threshold: 0.9989857077598572
Score > threshold → Active against S.aureus (+1 point)
Only evaluated for Broad-spectrum and Gram-positive targets

Hemolytic Score: Probability of hemolytic activity (0-1)

Threshold: 0.5
Score ≤ 0.5 → Non-hemolytic, safe for use (+1 point)
Score > 0.5 → Hemolytic, potentially toxic

Overall Evaluation

Score: Cumulative score based on all evaluated criteria

Good

Broad-spectrum: Score = 4/4 (AMP + E.coli + S.aureus + Non-hemolytic)
Single target: Score = 3/3 (AMP + target activity + Non-hemolytic)
Recommended for further validation

Mediocre

Broad-spectrum: Score = 2-3/4
Single target: Score = 2/3
Acceptable but may have limitations

Bad

Broad-spectrum: Score = 0-1/4
Single target: Score = 0-1/3
Not recommended for further study

💡 Note:
1. The scoring system adapts based on your selected target. Broad-spectrum targets evaluate both E.coli and S.aureus (max 4 points), while specific targets only evaluate the relevant pathogen (max 3 points).
2. If a peptide is clearly not an antimicrobial peptide, its sequence will be filtered out (for example, peptides longer than 50 amino acids or shorter than 5 amino acids) and will not appear in the final results.

⚠️ Important: These predictions are computational estimates. High-scoring peptides should be validated experimentally before clinical or commercial use.